Synonym: Aβ40 
Amino Acid Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val 
CAS Number: 131438-79-4 
Empirical Formula (Hill Notation): C194H295N53O58S 
Molecular Weight: 4329.80 
MDL number: MFCD00130509 
Description
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Reconstitution For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days. 
Biochem/physiol Actions Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.  

性质
assay ≥90% (HPLC) 
form powder 
color white 
solubility H2O: ~6 mg/mL 
  saline: insoluble 
storage temp. 20°C 
Gene Information Research your gene in Your Favorite Gene powered by Ingenuity
human ... APP(351) 

安全性
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
WGK Germany 3 

参考文献
reference Howlett, D.R., et al. Neurodegeneration 4, 23-32, (1995) Abstract 
  Aksenov, M.Y., et al. J. Mol. Neurosci. 10, 181-192, (1998) Abstract 
  Yankner, B.A., et al. Science 250, 279-282, (1990) Abstract 
  Ueda, K., et al. Brain Res. 639, 240-244, (1994) Abstract 
  Funato, H., et al. Am. J. Pathol. 152, 983-992, (1998) Abstract 
  Citron, M., et al. Proc. Natl. Acad. Sci. U. S. A. 93, 13170-13175, (1996) Abstract 
  Ball, K.K., et al., Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes. J. Cereb. Blood Flow Metab. 30, 162-76, (2010) Abstract 
Merck Merck 14,615