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上海信裕生物科技有限公司
FLCN抗体

FLCN抗体

商家询价

产品名称： FLCN抗体

英文名称： FLCNAntibody

产品编号： XY 11236-2-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 FLCN抗体

Applications
In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Published applications WB Publications 2 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Human, mouse
Images
Prev1NextView more validation data
  • 11236-2-AP;mouse thymus tissuemouse thymus tissue were subjected to SDS PAGE followed by western blot with 11236-2-AP(FLCN antibody) at dilution of 1:300
  • 11236-2-AP;HeLa cellsIP result of anti-FLCN(11236-2-AP) with Hela cell.
  • 11236-2-AP;human ovary tumorImmunohistochemical of paraffin-embedded human ovary tumor using 11236-2-AP(FLCN antibody) at dilution of 1:50 (under 40x lens)
Positive WB detected in Mouse thymus tissue, A549 cells, HeLa cells, mouse kidney tissue
Positive IP detected in HeLa cells
Positive IHC detected in Human ovary tumor tissue
Recommended dilution WB : 1:200-1:1000
IP : 1:200-1:1000
IHC : 1:20-1:200
 FLCN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen FLCN fusion protein ag1746 Full name Folliculin
Calculated molecular
weight		 38 kDa Observed molecular 
weight		 38-45 kDa,64 kDa,20-26 kDa
GenBank accession 
number		 BC015687 Gene ID (NCBI) 201163
Gene symbol FLCN Synonyms BHD, DKFZp547A118, FLCL, FLCN, FLJ45004, FLJ99377, folliculin
Background FLCN抗体

FLCN, also named as BHD, belongs to the folliculin family. It may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. It is involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutation of FLCN may cause the BHD(Birt-Hogg-Dube syndrome ) or (PSP) primary spontaneous pneumothorax. And it may be involved in renal cell carcinoma. This antibody can recognize all the 3 isoforms of FLCN. FLCN抗体

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