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上海信裕生物科技有限公司
STRAP抗体

STRAP抗体

商家询价

产品名称： STRAP抗体

英文名称： STRAPAntibody

产品编号： XY18277-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
  • 联系人 : 徐经理
  • 地址 : 上海市闵行莘庄工业区春东路508号A1-2F
  • 邮编 : 200612
  • 所在区域 : 上海
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 STRAP抗体Applications

In-house applications ELISA, WB, IHC, IP     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
Prev12NextView more validation data
  • 18277-1-AP;mouse brain tissuemouse brain tissue were subjected to SDS PAGE followed by western blot with 18277-1-AP(STRAP antibody) at dilution of 1:2000
  • 18277-1-AP;HeLa cellsIP Result of anti-STRAP (IP:18277-1-AP, 4ug; Detection:18277-1-AP 1:2000) with HeLa cells lysate 2000ug.
  • 18277-1-AP;H-ovaryImmunohistochemical of paraffin-embedded human ovary using 18277-1-AP(STRAP antibody) at dilution of 1:100 (under 10x lens)
  • 18277-1-AP;H-ovaryImmunohistochemical of paraffin-embedded human ovary using 18277-1-AP(STRAP antibody) at dilution of 1:100 (under 40x lens)
Positive WB detected in Mouse brain tissue, HeLa cells, HepG2 cells
Positive IP detected in HeLa cells
Positive IHC detected in Human ovary tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue
Recommended dilution WB : 1:1000-1:10000
IP : 1:1000-1:10000
IHC : 1:20-1:200
 STRAP抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen STRAP fusion protein ag13085 Full name Serine/threonine kinase receptor associated protein
Calculated molecular
weight		 38 kDa Observed molecular 
weight		 39 kDa
GenBank accession 
number		 BC000162 Gene ID (NCBI) 11171
Gene symbol STRAP Synonyms MAP activator with WD repeats, MAWD, PT WD, STRAP, UNR interacting protein, UNRIP, WD 40 repeat protein PT WD
Background STRAP抗体

STRAP (Serine-threonine kinase receptor-associated protein), also known as MAWD, is a ubiquitous WD40 domain protein, common function of which is to provide a suitable scaffold for coordinating multiprotein complex assemblies and thus, regulate a variety of cellular processes like signal transduction, transcriptional regulation, programmed cell death and so on. STRAP plays a role in the cellular distribution of the SMN complex, which is essential for spliceosomal snRNP assembly in the cytoplasm. STRAP inhibits transforming growth factor-beta (TGF-beta) signaling and enhances tumorigenicity via TGF-beta-dependent and -independent mechanisms. STRAP is up-regulated in several cancers and functions as an oncogene. STRAP imparts oncogenic characteristics to cells by promoting ERK and pRb phosphorylation. Moreover, STRAP regulates c-Jun stability by decreasing the ubiquitylation and proteosomal degradation of c-Jun. STRAP抗体

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