PCDHB3,原钙粘蛋白β3抗体

产品编号HZ-11154R
英文名称PCDHB3
中文名称原钙粘蛋白β3抗体
别 名Protocadherin beta 3; PCDH beta3; PCDHB 3; PCDHB3; PCDB3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞粘附分子 细胞骨架 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
PCDHB3,原钙粘蛋白β3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量84kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PCDHB3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PCDHB3,原钙粘蛋白β3抗体PubMedPubMed
产品介绍background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB3 (Protocadherin beta-3) is a 796 amino acid single pass transmembrane protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB3) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. PCDHB3 is likely a calcium-dependent cell adhesion protein that is involved in the maintenance of neural connections in the brain.

Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Similarity:
Contains 6 cadherin domains.

Gene ID:
56132

Database links:
Entrez Gene: 56132 Human
UniProtKB/Swiss-Prot: Q9Y5E6.1

PCDHB3,原钙粘蛋白β3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.